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Free download xtreme rat 3.65/1/2023 ![]() ![]() This rat model of blast demonstrated that the incidence of mild brain injury and or PTSD is significant and that affected animals demonstrated increased serum concentrations of cell free DNA. ![]() A significant increase in mean cell free DNA concentration was found at 2 hours after exposure in the affected group (741.40±47.18 ng/ml) compared to both the baseline concentration (372.42☑49.11 ng/ml), p<0.0001 and to the well-adapted group (517.47 ng/ml), p<0.0045. ![]() The rate of affected rats among the blast exposed animals was 42.5%. ResultsMean cell free DNA concentration increased significantly at 2 hours following the blast compared to baseline level and remained high throughout the follow-up period (665.43☑59.15 ng/ml vs. Cognitive and behavioral tests were used to diagnose affected rats. Cell free DNA concentrations were determined in the serum by a direct fluorescence method. This study tested the possible role of cell free DNA in the diagnosis of blast related head injuries in a rat model.MethodsA rat controlled model of a blast. Early diagnosis to enable interventions is important. Individuals being within non-lethal distance from explosion may present with blast induced mild traumatic brain injury, post traumatic stress disorder, or combination of the two conditions. ![]()
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